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- Primary Antibodies ›
- Collagen IV Antibodies
Invitrogen
View all (44) Collagen IV antibodies
Cite Collagen IV Polyclonal Antibody
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Collagen IV Antibody (PA5-104508) in WB
Western blot analysis of Collagen IV in 293 and HeLa (Lane 1: 293 cells, Lane 2: Hela cells, Lane 3: 293 cells treated with blocking peptide). Samples were incubated with Collagen IV polyclonal antibody (Product # PA5-104508). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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Product Details
PA5-104508
Applications
Tested Dilution
Publications
Western Blot(WB)
1:500-1:2,000
View 2 publications2 publications
Immunohistochemistry (Paraffin) (IHC (P))
1:50-1:200
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Product Specifications
Species Reactivity
Human,Mouse,Rat
Published species
Mouse
Host/Isotype
Rabbit/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human COL4A1(Accession P02462), corresponding to amino acid residues A27-Q77.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2853809
Product Specific Information
Antibody detects endogenous levels of total Collagen IV.
Target Information
Collagen IV is a type of collagen protein that is a major component of the basem*nt membrane in various tissues, including the kidneys, lungs, and skin. It forms a network-like structure that provides support and stability to the surrounding tissue. Collagen IV is composed of three alpha chains, which are encoded by the COL4A1, COL4A2, and COL4A3 genes. Mutations in these genes can lead to various genetic disorders, such as Alport syndrome and Goodpasture syndrome, which affect the kidneys and lungs, respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases:alpha 1 type IV collagen; alpha-2 collagen type IV; alpha1(IV) collagen; arresten; canstatin; COL4A1 NC1 domain; col4a3; col4a4; Collagen 4; Collagen alpha-1(IV) chain; Collagen alpha-2(IV) chain; Collagen alpha-3(IV) chain; Collagen alpha-4(IV) chain; Collagen alpha-5(IV) chain; collagen IV, alpha-1 polypeptide; collagen IV, alpha-3 polypeptide; Collagen IV, alpha-4 polypeptide; collagen IV, alpha-5 polypeptide; collagen of basem*nt membrane, alpha-1 chain; collagen of basem*nt membrane, alpha-4 chain; collagen of basem*nt membrane, alpha-5 chain; collagen type IV alpha3 chain; collagen type IV alpha5 chain; collagen, type IV, alpha 1; collagen, type IV, alpha 3 (Goodpasture antigen); collagen, type IV, alpha 4; collagen, type IV, alpha 5; dA149D17.3; dA24A23.1; Del(8)Bru44H; Goodpasture antigen; procollagen type IV alpha 5; procollagen, type IV, alpha 1; procollagen, type IV, alpha 2; procollagen, type IV, alpha 3; procollagen, type IV, alpha 4; procollagen, type IV, alpha 5; retinal anterior wiring; tumstatin; Type IV Collagen
Gene Aliases:[a]3(IV); [a]4(IV); alpha3(IV); ASLN; ATS; Bru; BSVD; CA44; CA54; Col4a-1; Col4a-2; COL4A1; COL4A2; COL4A3; COL4A4; COL4A5; Del(8)44H; E130010M05Rik; ICH; POREN2; RATOR; Raw; RGD1565499; Svc
UniProt ID:(Human) P02462, (Human) P08572, (Human) Q01955, (Human) P53420, (Human) P29400, (Mouse) Q6GQS7, (Mouse) P08122, (Mouse) Q9QZS0, (Mouse) Q9QZR9
Entrez Gene ID:(Human) 1282, (Human) 1284, (Human) 1285, (Human) 1286, (Human) 1287, (Rat) 290905, (Mouse) 12826, (Rat) 306628, (Mouse) 12827, (Rat) 363265, (Mouse) 12828, (Mouse) 12829, (Rat) 301562, (Mouse) 12830, (Rat) 363457
Molecular Function: 
extracellular matrix structural protein extracellular matrix protein
Function(s)
patterning of blood vesselsbrain developmentneuromuscular junction developmentextracellular matrix organizationcollagen catabolic processepithelial cell differentiationblood vessel morphogenesisretinal blood vessel morphogenesisrenal tubule morphogenesiscellular response to amino acid stimulusbasem*nt membrane organizationactivation of cysteine-type endopeptidase activity involved in apoptotic processcell adhesioncell surface receptor signaling pathwaysensory perception of soundblood circulationcell proliferationnegative regulation of cell proliferationnegative regulation of endopeptidase activitynegative regulation of angiogenesisglomerular basem*nt membrane developmentendothelial cell apoptotic processangiogenesistranscription, DNA-templatedendodermal cell differentiationcellular response to transforming growth factor beta stimulusresponse to glucosebiological_process
Process(es)
extracellular matrix structural constituentprotein bindingextracellular matrix constituent conferring elasticityplatelet-derived growth factor bindingintegrin bindingstructural molecule activitymetalloendopeptidase inhibitor activitymolecular_function
It has to be done as per old AB suggested Products section.
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